Transgenic human nephrin in Drosophila nephrocytes facilitates variant analysis
Our findings demonstrate that transgenesis of NPHS1 in nephrocytes is a viable approach for investigation of slit diaphragm formation and precise functional characterization of patient variants.
Authors
- Mengmeng Chen (ORCID: https://orcid.org/0000-0002-7201-0967)
- Ahmed Abed (ORCID: https://orcid.org/0000-0001-6678-3448)
- Maximilian H. Ulbrich (ORCID: https://orcid.org/0000-0001-8123-1668)
- Séverine Kayser
- Tobias Hermle (ORCID: https://orcid.org/0000-0002-0441-7749)
- Julian Milosavljevic (ORCID: https://orcid.org/0000-0002-7653-0011)
- Lea Gerstner (ORCID: https://orcid.org/0000-0002-9525-1288)
- Gerd Walz (ORCID: https://orcid.org/0000-0002-4950-9946)
- Sami Bahar
- Jonas O. Wolff (ORCID: https://orcid.org/0000-0003-2326-0326)
- Martin Helmstädter (ORCID: https://orcid.org/0000-0001-6027-0094)
- Konrad Lang (ORCID: https://orcid.org/0009-0003-6288-7794)
Institutions
- University of Freiburg (DE)
- An-Najah National University (PS)
- University Medical Center Freiburg (DE)
Publication Details
- Journal
- Kidney International
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1016/j.kint.2025.03.030
- Citations
- 1
- Primary Topic
- Renal Diseases and Glomerulopathies
- Type
- article
- Field-Weighted Citation Impact
- 1.43