Salt-Induced Vascular Damage in Hypertension Involves Redox Activation of PARP/TRPM2 Signaling and Inflammasome Assembly
Salt-induced vascular injury in hypertension involves ROS generation in VSMCs leading to activation of the PARP/TRPM2 axis, increased Ca2+ influx, NLRP3 activation, and vascular injury. Our study provides new insights into molecular pathways involved in high-salt diet-induced vascular dysfunction, important in hypertension.
Authors
- Augusto C. Montezano (ORCID: https://orcid.org/0000-0002-8658-7994)
- Rhian M. Touyz (ORCID: https://orcid.org/0000-0003-0670-0887)
- Delyth Graham (ORCID: https://orcid.org/0000-0002-7328-4708)
- Christian Delles (ORCID: https://orcid.org/0000-0003-2238-2612)
- Rhéure Alves-Lopes (ORCID: https://orcid.org/0000-0002-4885-6647)
- Karla B Neves (ORCID: https://orcid.org/0000-0001-5158-9263)
- Sheon Mary
Institutions
- University of Strathclyde (GB)
- University of Aberdeen (GB)
- McGill University Health Centre (CA)
- McGill University (CA)
- University of Glasgow (GB)
Publication Details
- Journal
- American Journal of Hypertension
- Published
- 2025-04-27
- DOI
- https://doi.org/10.1093/ajh/hpaf071
- Citations
- 3
- Primary Topic
- Ion Channels and Receptors
- Type
- article
- Field-Weighted Citation Impact
- 4.39
Funders
- McGill University
- British Heart Foundation
- Foulkes Foundation
- Tenovus
- University of Glasgow
- Fondation Leducq
- Canadian Institutes of Health Research