Cognitive improvement effects of PF-04957325, a phosphodiesterase-8 inhibitor, in mouse models of Alzheimer’s disease via modulating neuroinflammation
PF alleviated AD-like changes in behavior and pathology through various mechanisms, including attenuating microglia-mediated neuroinflammation, upregulating the expression of BDNF, restoring synaptic dysfunction, and inhibiting Aβ generation, which appear to be involved by PDE8/cAMP/CREB signaling. These results highlight the therapeutic potential of targeting PDE8 inhibition for AD treatment.
Authors
- Fang‐fang Zhang (ORCID: https://orcid.org/0000-0002-9348-7596)
- Yongfeng Gao (ORCID: https://orcid.org/0000-0003-1467-9192)
- Ruimin Chen (ORCID: https://orcid.org/0000-0002-2768-644X)
- Nianzhuang Qiu (ORCID: https://orcid.org/0009-0007-6786-1269)
- Han‐Ting Zhang
- Xiaodan Wang (ORCID: https://orcid.org/0000-0003-0216-5135)
- Feng Zhang (ORCID: https://orcid.org/0000-0003-0733-9288)
- Xuehui Zhang (ORCID: https://orcid.org/0000-0003-1016-6488)
- Hao Wang (ORCID: https://orcid.org/0000-0002-0901-5183)
- Tianyang Guo (ORCID: https://orcid.org/0000-0001-7761-1721)
- Meihua Chen
- Yu-li Lv
- Wei Chen (ORCID: https://orcid.org/0000-0003-3348-4710)
- Meng Zhang (ORCID: https://orcid.org/0000-0002-6238-4148)
Institutions
- Qingdao University (CN)
- Academy of Medical Sciences (GB)
- Qingdao Agricultural University (CN)
- Yantai University (CN)
- Luye Pharma (China) (CN)
- Shandong First Medical University (CN)
- Institute of Pharmacology (CZ)
Publication Details
- Journal
- The International Journal of Neuropsychopharmacology
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1093/ijnp/pyaf028
- Citations
- 3
- Primary Topic
- Phosphodiesterase function and regulation
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- National Natural Science Foundation of China
- Shandong First Medical University