Charting the single-cell and spatial landscape of IDH-wild-type glioblastoma with GBmap
This study provides a comprehensive resource for understanding glioblastoma heterogeneity and spatial organization. GBmap and the TSS provide an integrative view of tumor architecture in GB, highlighting hypoxia-driven niches that may represent avenues for further investigation. Our resource can facilitate exploratory analyses and hypothesis generation to better understand disease progression.
Authors
- Mats F. Nilsson (ORCID: https://orcid.org/0000-0001-9985-0387)
- Mariia Minaeva (ORCID: https://orcid.org/0000-0001-7028-1264)
- Ananya Roy (ORCID: https://orcid.org/0000-0002-0706-3237)
- Hendrik G. Stunnenberg (ORCID: https://orcid.org/0000-0002-0066-1576)
- Mariëtte E.G. Kranendonk (ORCID: https://orcid.org/0000-0001-9683-7494)
- Karin Forsberg‐Nilsson (ORCID: https://orcid.org/0000-0003-0692-6245)
- Marco Grillo (ORCID: https://orcid.org/0000-0003-2155-0645)
- Erik Samuelsson (ORCID: https://orcid.org/0000-0002-5622-288X)
- Fabian Joachim Theis (ORCID: https://orcid.org/0000-0002-2419-1943)
- Cristian Ruiz-Moreno (ORCID: https://orcid.org/0000-0001-9689-7964)
- Sergio Marco Salas (ORCID: https://orcid.org/0000-0002-0037-5166)
- Sebastian Brandner (ORCID: https://orcid.org/0000-0002-8635-7195)
- Ignacio Ibarra
Institutions
- Uppsala University (SE)
- Radboud University Nijmegen (NL)
- Stockholm University (SE)
- Science for Life Laboratory (SE)
- Center for Environmental Health (US)
- Radboud University Medical Center (NL)
- Helmholtz Zentrum München (DE)
- Radboud Institute for Molecular Life Sciences (NL)
- Princess Máxima Center (NL)
- National Hospital for Neurology and Neurosurgery (GB)
- University College London (GB)
Publication Details
- Journal
- Neuro-Oncology
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1093/neuonc/noaf113
- Citations
- 33
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 26.60
Funders
- Silicon Valley Community Foundation
- European Commission
- Cancerfonden
- Knut och Alice Wallenbergs Stiftelse
- Vetenskapsrådet
- Stichting Kinderen Kankervrij