The evaluation and molecular mechanisms of hepatotoxicity induced by trans-emodin dianthrones isolated from Polygonum multiflorum Thunb. in vitro
Trans-emodin dianthrones exhibited significant hepatotoxicity at the level of HepG2 cells, and its mechanism is related to inhibiting the antioxidant system, causing mitochondrial dysfunction and inducing apoptosis induced by JNK/Bax and PI3K/AKT/mTOR pathways.
Authors
- Hongtao Jin (ORCID: https://orcid.org/0000-0002-0638-707X)
- Ying Wang (ORCID: https://orcid.org/0000-0002-9659-3538)
- Wanfang Li (ORCID: https://orcid.org/0000-0002-2544-1756)
- Haiyun Zheng
- Shuting Wang (ORCID: https://orcid.org/0000-0003-1461-3898)
- Jie Li (ORCID: https://orcid.org/0000-0003-3902-642X)
- Jie Bao
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- National Institutes for Food and Drug Control (CN)
- China Academy of Chinese Medical Sciences (CN)
Publication Details
- Journal
- Journal of Ethnopharmacology
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1016/j.jep.2025.119916
- Citations
- 3
- Primary Topic
- Phytochemistry and biological activity of medicinal plants
- Type
- article
- Field-Weighted Citation Impact
- 5.25