Genetic Polymorphisms of <i>TP53</i> and <i>ApoB</i> Genes and Risk of Biliary Tract Cancer: A Case–Cohort Study in Japan
This prospective study highlights the effect of TP53 rs1042522 on BTC risk in Japanese individuals. Identifying carriers of the high-risk CC genotype may facilitate targeted surveillance and early detection strategies, potentially reducing mortality and improving outcomes. Further large-scale studies are required to clarify environmental interactions and optimize prevention.
Authors
- Toshikazu Ikoma (ORCID: https://orcid.org/0000-0002-3351-7394)
- Yasuo Tsuchiya (ORCID: https://orcid.org/0000-0003-2623-0368)
- Motoki Iwasaki (ORCID: https://orcid.org/0000-0003-3319-4131)
- Takao Asai (ORCID: https://orcid.org/0000-0002-3536-5072)
- Shoichiro Tsugane (ORCID: https://orcid.org/0000-0003-4105-2774)
- Taiki Yamaji (ORCID: https://orcid.org/0000-0002-4799-8782)
- Shiori Nakano (ORCID: https://orcid.org/0000-0001-5762-850X)
- Norie Sawada (ORCID: https://orcid.org/0000-0002-9936-1476)
- Manami Inoue (ORCID: https://orcid.org/0000-0003-1276-2398)
- Kazutoshi Nakamura (ORCID: https://orcid.org/0000-0002-8618-7632)
Institutions
- Juntendo University (JP)
- National Cancer Centre Japan (JP)
- Fukuoka Tokushukai Hospital (JP)
- Prevention Group (US)
- Niigata University Medical and Dental Hospital (JP)
- Juntendo University Urayasu Hospital (JP)
- National Cancer Research Institute (GB)
- Niigata University (JP)
- International University of Health and Welfare (JP)
Publication Details
- Journal
- Cancer Prevention Research
- Published
- 2025-05-02
- DOI
- https://doi.org/10.1158/1940-6207.capr-24-0536
- Primary Topic
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- RIKEN