The effect of overnight culture after thawing of D3 cleavage-stage embryos on clinical pregnancy outcomes: focus on embryo development to day 4
This study indicates that D3 embryos with an increase in the number of blastomeres to more than four or entering the compaction stage after overnight culture have better pregnancy outcomes. Female age and endometrial thickness are important factors influencing clinical pregnancy rates. Optimizing culture conditions and ensuring optimal endometrial thickness may help improve the success rate of frozen-thawed embryo transfer.
Authors
- Zengyu Yang
- Jian Wen
- Yudi Luo
- Weiwu Liu
- Derong Li (ORCID: https://orcid.org/0000-0002-7689-7921)
- Lingling Zhu (ORCID: https://orcid.org/0000-0003-1794-3147)
- Guosheng Deng (ORCID: https://orcid.org/0000-0002-1684-8095)
- Keng Feng (ORCID: https://orcid.org/0009-0009-7472-5227)
- Lixiang Lan
- Bowen Luo
- J. Zhang
- Feifei Lei
- Xiang Li (ORCID: https://orcid.org/0009-0009-6746-3580)
Institutions
- Qinzhou Maternity and Child Health Care Hospital (CN)
- Yulin Orthopedics Hospital of Chinese and Western Medicine (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-05-01
- DOI
- https://doi.org/10.3389/fendo.2025.1530112
- Citations
- 2
- Primary Topic
- Reproductive Biology and Fertility
- Type
- article
- Field-Weighted Citation Impact
- 3.76