Integrative multi-omics and Mendelian randomization analysis reveal SPP1+ tumor-associated macrophage-driven prognostic signature for hepatocellular carcinoma
This study identified SPP1<sup>+</sup> TAMs-related genes as key prognostic indicators in HCC. The STRS model provides an effective tool for predicting patient survival and may facilitate personalized treatment strategies for HCC. These findings enhance the understanding of TAMs-driven immune modulation in HCC and highlight potential therapeutic targets for improving patient outcomes.
Authors
- Yifan Zhang (ORCID: https://orcid.org/0000-0001-6488-6232)
- Kai Lei (ORCID: https://orcid.org/0000-0001-9085-9801)
- Yuanbao Lei
- Jade M. Tan (ORCID: https://orcid.org/0000-0003-3677-7666)
- Jiawei Liu (ORCID: https://orcid.org/0000-0002-5794-1683)
- Zeyao Wang
- Zhixin Ye
- Wenhao Chen (ORCID: https://orcid.org/0000-0002-0626-3739)
- Caihong Zhou
- Shuxian Chen
Institutions
- Jiangxi University of Traditional Chinese Medicine (CN)
- Sun Yat-sen University (CN)
- Central People's Hospital of Zhanjiang (CN)
- Nanfang Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Third Affiliated Hospital of Sun Yat-sen University (CN)
- Qujiang People's Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Frontiers in Molecular Biosciences
- Published
- 2025-05-01
- DOI
- https://doi.org/10.3389/fmolb.2025.1594610
- Citations
- 4
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 3.22