A phase II study of monalizumab and durvalumab in patients with recurrent/metastatic squamous cell carcinoma of the head and neck: results of the I2 cohort of the EORTC-HNCG-1559 trial (UPSTREAM)
The I2 substudy failed to demonstrate an activity of D + M in heavily pretreated patients with SCCHN previously exposed to anti-PD(L)1. No benefit was seen in PFS and OS.
Authors
- Marika Rasschaert (ORCID: https://orcid.org/0000-0003-3051-6481)
- Christian Borel (ORCID: https://orcid.org/0000-0002-7710-2086)
- Cyril Abdeddaim
- Frédéric Rolland (ORCID: https://orcid.org/0000-0001-6957-0894)
- Christine Olungu
- Emmanuel Seront (ORCID: https://orcid.org/0000-0003-4807-7472)
- Ingeborg Tinhofer (ORCID: https://orcid.org/0000-0002-0512-549X)
- Anne-Sophie Govaerts (ORCID: https://orcid.org/0009-0001-4575-9454)
- Lisa Francesca Licitra (ORCID: https://orcid.org/0000-0003-0623-4118)
- Catherine Fortpied (ORCID: https://orcid.org/0000-0003-3927-1214)
- Christophe Le Tourneau (ORCID: https://orcid.org/0000-0001-9772-4686)
- Pierluigi Bonomo (ORCID: https://orcid.org/0000-0001-8999-5208)
- Jean‐Pascal Machiels (ORCID: https://orcid.org/0000-0001-6369-9742)
- Anthony Kong (ORCID: https://orcid.org/0000-0002-3989-3948)
- Rachel Galot (ORCID: https://orcid.org/0000-0002-0596-4752)
- Stéphanie Henry (ORCID: https://orcid.org/0000-0002-4704-4647)
- Ana Joaquim (ORCID: https://orcid.org/0000-0001-7064-9639)
- A. Rutten
- Amaury Daste (ORCID: https://orcid.org/0000-0001-5621-812X)
- J. Guigay
- J.B. Prevost
- Konstantina Tsechilidou
- Esma Saâda-Bouzid
- L. Dirix
- Caroline Even
Institutions
- Inserm (FR)
- King's College London (GB)
- Universitair Ziekenhuis Leuven (BE)
- Institut Gustave Roussy (FR)
- Sorbonne Université (FR)
- Institut de Cancérologie Strasbourg (FR)
- CHU Dinant Godinne UCL Namur (BE)
- GZA Ziekenhuizen Campus Sint-Augustinus (BE)
- Institut de Cancérologie de l'Ouest (FR)
- Hôpital Saint-André (FR)
- Azienda Ospedaliero-Universitaria Careggi (IT)
- European Organisation for Research and Treatment of Cancer (BE)
- Universitair Ziekenhuis Brussel (BE)
- Centre Oscar Lambret (FR)
- Ziekenhuisnetwerk Antwerpen Stuivenberg (BE)
- Centre Antoine Lacassagne (FR)
- Fondazione IRCCS Istituto Nazionale dei Tumori (IT)
- University of Florence (IT)
- Charité - Universitätsmedizin Berlin (DE)
- Institut Curie (FR)
- UCLouvain (BE)
Publication Details
- Journal
- ESMO Open
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1016/j.esmoop.2025.104554
- Citations
- 1
- Primary Topic
- Head and Neck Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.85
Funders
- AstraZeneca
- AstraZeneca Foundation