Identification and external validation of tumor DNA methylation panel for the recurrence risk stratification of stage II colon cancer
This study identified 27 tumor tissue DNA methylation biomarkers that improved the discriminative power in classifying recurrence risk among stage II colon cancer patients. While this methylation panel alone lacks sufficient prediction accuracy for clinical application, its discriminative improvement suggests potential value as part of a multimodal risk-stratification tool.
Authors
- Tanwei Yuan (ORCID: https://orcid.org/0000-0001-7387-6327)
- Katrin E. Tagscherer (ORCID: https://orcid.org/0000-0002-0657-6399)
- Elisabeth Georgii (ORCID: https://orcid.org/0000-0002-7511-5510)
- Xiaofeng Jiang (ORCID: https://orcid.org/0000-0002-3716-8232)
- Lisa Barros de Andrade e Sousa (ORCID: https://orcid.org/0000-0001-7702-9782)
- Alexander Brobeil (ORCID: https://orcid.org/0000-0002-1003-8577)
- Michael Hoffmeister (ORCID: https://orcid.org/0000-0002-8307-3197)
- Melanie Bewerunge‐Hudler (ORCID: https://orcid.org/0000-0001-9038-7891)
- Vı́ctor Moreno (ORCID: https://orcid.org/0000-0002-2818-5487)
- Hermann Brenner (ORCID: https://orcid.org/0000-0002-6129-1572)
- Hendrik Bläker
- Wilfried Roth
- Matthias Kloor
- Jakob Nikolas Kather
- Dominic Edelmann
- Helena Pelin
Institutions
- German Cancer Research Center (DE)
- Johannes Gutenberg University Mainz (DE)
- Heidelberg University (DE)
- Bellvitge University Hospital (ES)
- University Hospital Heidelberg (DE)
- Helmholtz Zentrum München (DE)
- University Medical Center of the Johannes Gutenberg University Mainz (DE)
- Institut Català d'Oncologia (ES)
- Fresenius (Germany) (DE)
- Leipzig University (DE)
Publication Details
- Journal
- Translational Oncology
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1016/j.tranon.2025.102405
- Citations
- 1
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.47