PU.1 dictates β-amyloid-induced TREM2 expression upregulation in microglia in a transgenic model of Alzheimer’s disease
Our findings reveal a novel regulatory mechanism where PU.1 directly modulates TREM2 transcription in activated microglia during AD progression. These insights highlight the potential of TREM2 and PU.1 as therapeutic targets in AD treatment.
Authors
- Xiaoman Dai (ORCID: https://orcid.org/0000-0003-3409-5936)
- Yuqi Zeng (ORCID: https://orcid.org/0000-0001-9882-9156)
- Xiaodong Pan (ORCID: https://orcid.org/0000-0001-9511-6986)
- Jing Zhang (ORCID: https://orcid.org/0000-0002-7222-8317)
- Xiaochun Chen (ORCID: https://orcid.org/0000-0001-6619-0175)
- Xiaoli Cui (ORCID: https://orcid.org/0000-0002-8425-6278)
- Zhen Wei (ORCID: https://orcid.org/0000-0002-5148-7651)
Institutions
- Fujian Medical University (CN)
- Fujian Provincial Hospital (CN)
- Union Hospital (CN)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2025-05-01
- DOI
- https://doi.org/10.3389/fnagi.2025.1537388
- Citations
- 2
- Primary Topic
- Inflammation biomarkers and pathways
- Type
- article
- Field-Weighted Citation Impact
- 1.59