Modified triglyceride-glucose indices as novel predictors of metabolic dysfunction-associated fatty liver disease in US adolescents: a nationally representative study from NHANES 2017–2020
This study demonstrates that modified TyG indices incorporating anthropometric parameters (particularly TyG-WC) significantly outperform the original TyG index for MAFLD detection in adolescents, with superior diagnostic accuracy (AUC 0.915-0.923). The robust predictive performance maintained in sensitivity analyses and non-obese subgroups supports their clinical utility as simple, non-invasive screening tools for pediatric MAFLD risk stratification.
Authors
- Hu Chen (ORCID: https://orcid.org/0000-0003-3297-2747)
- Qinghua Yang (ORCID: https://orcid.org/0000-0001-7390-0665)
- Zhaomeng Zhuang (ORCID: https://orcid.org/0000-0002-5328-2465)
- Yigui Zou
- Wenwen Li (ORCID: https://orcid.org/0000-0002-9036-4179)
- Ziyuan Li (ORCID: https://orcid.org/0000-0002-6759-0717)
- Yu Dai (ORCID: https://orcid.org/0000-0001-7929-2760)
- Dongling Dai (ORCID: https://orcid.org/0000-0003-4808-3418)
- Betty P.C. Lin
Institutions
- Shenzhen Children's Hospital (CN)
Publication Details
- Journal
- BMC Gastroenterology
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1186/s12876-025-03915-x
- Citations
- 4
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 5.42
Funders
- Shenzhen Science and Technology Innovation Program