Integrative single-cell RNA sequencing and bulk RNA sequencing reveals the characteristics of glutathione metabolism and protective role of GSTA4 gene in pancreatic cancer
The GSH metabolism-associated prognostic signature developed in this study effectively identifies high-risk patients with PC. As a prognostic protective factor, GSTA4 exhibits downregulated expression in PC tissues and suppresses tumor proliferation and migration, highlighting its potential as a therapeutic target.
Authors
- Jianliang Cao (ORCID: https://orcid.org/0000-0003-3570-5185)
- Yuepeng Hu
- Anran Song
- Qiang Zhang (ORCID: https://orcid.org/0000-0002-7248-6244)
- Zhe Wang (ORCID: https://orcid.org/0000-0003-4036-7969)
- Ching-Ying Lan (ORCID: https://orcid.org/0000-0002-2802-3322)
- X. Jia
Institutions
- Zhengzhou University (CN)
- Henan Provincial People's Hospital (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-05-01
- DOI
- https://doi.org/10.3389/fimmu.2025.1571431
- Citations
- 1
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.81