Comparison of cerebrospinal fluid biomarkers in patients with severe COVID-19 neurological outcomes and Alzheimer’s disease
Collectively, our findings reveal that CSF tau levels are comparably elevated in COVID-19 neurological patients and AD, suggesting ongoing neurodegeneration in COVID-19 neurological disease, but no biomarker alterations related to AD pathology. Furthermore, CNS AD-related biomarker levels in COVID-19 patients change in association with disease severity and systemic inflammation. Considering that inflammation may persist post-COVID, our findings urge the assessment of possible AD-related biomarker changes in COVID-19 survivors with lingering symptoms.
Authors
- Fernanda G. Q. Barros‐Aragão (ORCID: https://orcid.org/0000-0002-1663-8346)
- TC Pinheiro (ORCID: https://orcid.org/0000-0001-9762-3148)
- Fernanda G. De Felice (ORCID: https://orcid.org/0000-0001-8358-0589)
- Andrea Silveira de Souza (ORCID: https://orcid.org/0000-0002-1553-2312)
- Gabriel R. de Freitas (ORCID: https://orcid.org/0000-0003-3178-0460)
- Felipe Kenji Sudo (ORCID: https://orcid.org/0000-0003-4738-1368)
- Talita P. Pinto (ORCID: https://orcid.org/0000-0002-2461-7203)
- Érika C. Rodrigues (ORCID: https://orcid.org/0000-0001-5464-2963)
- Fernanda Tovar‐Moll
- Bart Vanderborgh
- Fernando A. Bozza (ORCID: https://orcid.org/0000-0003-4878-0256)
- Guilherme B. de Freitas (ORCID: https://orcid.org/0000-0003-4614-4280)
- Nathane Rezende
- Paulo Mattos (ORCID: https://orcid.org/0000-0003-0709-3783)
- Carlos Otávio Brandão (ORCID: https://orcid.org/0000-0002-4898-5916)
Institutions
- Universidade Federal do Rio de Janeiro (BR)
- Queen's University (CA)
- D’Or Institute for Research and Education (BR)
Publication Details
- Journal
- Brain Behavior & Immunity - Health
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1016/j.bbih.2025.101007
- Citations
- 1
- Primary Topic
- Long-Term Effects of COVID-19
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- Instituto D'Or de Pesquisa e Ensino
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
- Ministério da Saúde