Comprehensive analysis of SQOR involvement in ferroptosis resistance of pancreatic ductal adenocarcinoma in hypoxic environments
This study has established a hypoxia detection model of PDAC based on WSIs, providing a new tool for clinical evaluation. The study revealed a new mechanism of SQOR mediating ferroptosis resistance under hypoxia and provided a basis for targeted therapy.
Authors
- Minghui Peng
- Haibo Yu (ORCID: https://orcid.org/0009-0000-1020-6668)
- Shiwei Guan (ORCID: https://orcid.org/0009-0001-5629-6109)
- Hui Zhang (ORCID: https://orcid.org/0000-0002-5426-2140)
- Quan Lin (ORCID: https://orcid.org/0000-0002-9255-3555)
- Taoming Mo
- Kailun Zhang (ORCID: https://orcid.org/0000-0002-9147-5006)
Institutions
- Nantong University (CN)
- Wenzhou Medical University (CN)
- Wenzhou Central Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-05-01
- DOI
- https://doi.org/10.3389/fimmu.2025.1513589
- Citations
- 2
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 3.04