Independent and synergistic roles of MEK-ERK1/2 and PKC pathways in regulating functional changes in vascular tissue following flow cessation
The MEK and PKC pathways independently drive functional changes in vascular tissue, particularly following flow cessation. MEK inhibition is effective early, while PKC inhibition remains effective when applied later. The additive effects observed with combined MEK and PKC inhibition indicate parallel and functionally independent pathway activation during ET<sub>B</sub> receptor upregulation.
Authors
- Lars Edvinsson (ORCID: https://orcid.org/0000-0002-1805-1346)
- Kristian Agmund Haanes (ORCID: https://orcid.org/0000-0001-5182-8957)
- Spyridoula Kazantzi
Institutions
- University of Copenhagen (DK)
- Lund University (SE)
- Glostrup Hospital (DK)
- Copenhagen University Hospital (DK)
- Rigshospitalet (DK)
Publication Details
- Journal
- Journal of Molecular and Cellular Cardiology Plus
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1016/j.jmccpl.2025.100300
- Primary Topic
- Acute Ischemic Stroke Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Gentofte Hospital
- Lundbeckfonden
- Rigshospitalet
- H. Lundbeck A/S