A-78 | Outcomes of ST Segment Elevation Myocardial Infarction in Patients With Body Mass Index Above 25

Background: The coexistence of acute myocardial infarction and gastrointestinal (GI) bleeding presents a clinical challenge.However, the prevalence, complications, and outcomes of non-ST elevation myocardial infarction (NSTEMI) in patients with GI bleeding remain inadequately studied.Methods: We analyzed hospitalized patients with GI bleeding from the National Inpatient Sample (2016)(2017)(2018)(2019)(2020).GI bleeding and NSTEMI were identified using ICD-10 codes.Patients younger than 18 years were excluded.Multivariable logistic regression was performed to examine the association between NSTEMI and outcomes.Results: Among 2,269,809 patients with GI bleeding, 1.40% (mean age 74.8 AE 11.3 years; 41.3% female; 74.6% White) were diagnosed with NSTEMI.Mortality was significantly higher in the NSTEMI group (8% vs. 2% in non NSTEMI patients).The most common complications in the NSTEMI group included acute kidney injury (40%), atrial fibrillation/flutter (22%), and shock (14%).NSTEMI was independently associated with increased mortality (OR 3.3, 95% CI 2.95-3.63,p < 0.001) and complications (OR 2.05, 95% CI 1.93-2.17,p < 0.001) as shown in Figure a. 47% of the NSTEMI patients required blood transfusions.GI endoscopy was performed in 47.6%, and percutaneous coronary intervention was undertaken in 9%.The mean length of stay was 6.7 days, with inflation-adjusted average total charges $101,047.Conclusions: NSTEMI is an uncommon but serious comorbidity in patients hospitalized with GI bleeding.It is associated with increase in mortality, and complications.Early recognition and tailored management of NSTEMI in this population are essential to improve outcomes.