202. Evaluation of Wound Healing Characteristics Utilizing Dehydrated Human Amnion/chorion Membrane After Mohs Micrographic Surgical Excision

PURPOSE: Conventional healing methods following Mohs surgery such as secondary intention healing and local flap usage can prolong healing times and introduce secondary wounds/scars, respectively. Dehydrated human amnion/chorion membrane allografts such as Epifix (MiMedx, Marietta, GA), have emerged as promising adjuncts in this reconstructive process by providing scaffolds that mimic the natural architecture of the skin allowing for more uniform re-epithelialization and decreased healing times. This study will evaluate the wound healing characteristics following Epifix usage in post-Mohs surgical wounds. METHODS: 46 patients who underwent Mohs surgery had reconstructive procedures utilizing Epifix. A retrospective analyisis of demographic information and operative variables including: age, race, cancer type, smoking history, body mass index, wound location, wound size, wound depth, healing time, number of treatments, graft usage, and graft size. RESULTS: Of the 46 patients, 19 were women and 27 were men. The mean age was 73 years. 9 patients had squamous cell carcinoma and 37 had basal cell carcinoma. The mean wound size was 2.64 cm2. The mean number of Epifix treatments was 2.26. 34 of the 46 patients received full thickness skin grafts post treatment. The mean healing time from the date of Mohs surgery and first Epifix application was 42 days. The cohort stratified by wound size, location, and depth are shown. CONCLUSION: The application of Epifix following Mohs surgery provides favorable healing times when compared to previous methods. Nasal subunits such as the nasal dorsum and alar required significantly less treatments when compared to the nasal tip. No significant differences in wound healing times were found when stratifying by size, location, and depth. Future studies will include larger cohorts with greater variation in wound size and location as well as compare aesthetic outcomes of Epifix as compared to other reconstructive methods.