F-70 | Impact of Hyperferritinemia on Clinical Outcomes Following Lower Extremity Revascularization in Peripheral Arterial Disease: A Propensity-Matched Analysis

Background: Patients with malignancies are vulnerable to peripheral artery disease (PAD) due to shared risk factors, prothrombotic states and inflammation.The impact of PAD on mortality and its trends and disparities in this population remain underexplored.Methods: We analyzed Center for Disease Control and Prevention Wide-Ranging Online Data 1999-2020 to assess trends in PAD-related mortality among patients with malignancy, stratified by sex, ethnicity, census region and urbanization.Age-adjusted mortality rates (AAMR) per 100,000 and annual percent change (APC) were calculated.Results: PAD-related AAMR was higher in males than females (1.3 CI [1.3-1.3] vs. 0.6 [0.6-0.6]), with significant increases in recent years: 2016-20 for females (APC 9.55%, p<0.05) and 2018-20 for males (APC 8.85%, p<0.05,Fig A).AAMR was higher in African Americans than Caucasians (1.1 [1.0-1.1] vs. 0.9 [0.9-0.9],Fig B).African Americans showed no significant trends, while Caucasians had significant declines 2003-06 and 2012-16 followed by an increase in 2016-20.AAMR was higher in non-Hispanics than in Hispanics (0.9 [0.9-0.9] vs. 0.4 [0.4-0.4],Fig C).Less urban areas had higher AAMRs (Fig D).Regionally, the Midwest had the highest AAMRs (Fig E).Increases in AAMR in 2018-20 affected every region.Conclusions: PAD-associated mortality among patients with malignancy varies by gender, ethnicity, urbanization and region.Targeted strategies are needed to reduce disparities and improve vascular care in high-risk populations.