Confirmation of Tuberculous Meningitis Using Metagenomic Next-Generation Sequencing: A Case Report
The patient's condition improved after 5 days of treatment. TBM is notoriously challenging to diagnose and treat. Traditional diagnostic methods, such as smear microscopy and tuberculosis culture, often yield low positive rates, delaying timely diagnosis and intervention. Early detection, accurate diagnosis, and prompt treatment are crucial for improving patient outcomes. mNGS of CSF has proven to be a powerful tool in TBM diagnosis, enabling early and precise identification of the pathogen, thereby facilitating timely treatment and reducing TBM-related mortality.
Authors
- Jingwen Lyu
- Kaixuan Yuan
- Steve W. Cui (ORCID: https://orcid.org/0000-0001-5864-4544)
- Mengdi Lu (ORCID: https://orcid.org/0000-0001-6526-1955)
- Xiaoli Chen (ORCID: https://orcid.org/0000-0003-0536-1553)
- Changyu Liu (ORCID: https://orcid.org/0000-0003-2717-3684)
- Long Ye
- Yanjuan Cai (ORCID: https://orcid.org/0000-0002-1710-3714)
- Yangxi Deng
- Yong Ling (ORCID: https://orcid.org/0009-0004-2013-4417)
Institutions
- Fudan University (CN)
- Zhongshan People's Hospital (CN)
- Guangdong Academy of Medical Sciences (CN)
Publication Details
- Journal
- Infection and Drug Resistance
- Published
- 2025-05-01
- DOI
- https://doi.org/10.2147/idr.s519905
- Primary Topic
- Infectious Diseases and Tuberculosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Guangdong Provincial People's Hospital