IGFBP5 mediates the therapeutic effect of isoliquiritigenin in myocardial ischemia-reperfusion injury via AKT/GLUT4 regulated insulin resistance
Our results reveal that ISL protects against myocardial damage caused by MIRI through the regulation of IR via the IGFBP5/AKT/GLUT4 pathway.
Authors
- Ying Cao
- Shao-Mei Yu
- Xuanyi Hu
- Cary Ma
- Hongjin Chen (ORCID: https://orcid.org/0009-0002-1820-2244)
- Siyuan Yang (ORCID: https://orcid.org/0000-0002-2636-9610)
- Xiong Chen
- Yingnan Song
- Jue Bai
Institutions
- Guiyang Medical University (CN)
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
- Affiliated Hospital of Guizhou Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-04-29
- DOI
- https://doi.org/10.3389/fphar.2025.1544869
- Citations
- 1
- Primary Topic
- Pharmacological Effects of Natural Compounds
- Type
- article
- Field-Weighted Citation Impact
- 1.56
Funders
- National Natural Science Foundation of China
- Guizhou Medical University
- Science and Technology Program of Guizhou Province