Tetramethylpyrazine alleviates acute pancreatitis inflammation by inhibiting pyroptosis via the NRF2 pathway
TMPZ mitigates AP-induced inflammation and injury by modulating pyroptosis via the NRF2 signaling pathway. These findings suggest TMPZ's therapeutic potential for AP.
Authors
- Xiaotong Ye (ORCID: https://orcid.org/0000-0003-2934-4256)
- Minglian Huang
- Qingqing Wu (ORCID: https://orcid.org/0000-0002-7475-5014)
- Huangen Li
- Weiwen Chen (ORCID: https://orcid.org/0000-0003-4940-7445)
- Hongling Zhang (ORCID: https://orcid.org/0000-0002-6182-0710)
- Youpei Huang
- Yi Gao
Institutions
- Huaqiao University (CN)
- Fujian Medical University (CN)
- First Affiliated Hospital of Xiamen University (CN)
- Xiamen Chang Gung Hospital (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-04-23
- DOI
- https://doi.org/10.3389/fphar.2025.1557681
- Citations
- 3
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- Natural Science Foundation of Fujian Province