Whole-Genome DNA Methylation Analysis in Age-Related Hearing Loss
Altered DNA methylation and its impact on gene expression has been implicated in many biological processes. By interrogating the methylation status across the genome of both hearing loss patients and those with normal hearing, our study can help to establish an association between the audiometric patterns and methylation status in ARHL, yielding new avenues for the identification of potential candidate genes for hearing loss.
Authors
- Juan I. Young
- Denise Yan (ORCID: https://orcid.org/0000-0002-9074-4817)
- Marie Valerie Roche (ORCID: https://orcid.org/0000-0001-7924-0645)
- Susan H. Blanton (ORCID: https://orcid.org/0000-0002-5433-3439)
- Feng Gong (ORCID: https://orcid.org/0000-0002-3806-1621)
- Yan Guo (ORCID: https://orcid.org/0000-0001-5252-3960)
- Naser Hamad (ORCID: https://orcid.org/0009-0008-3281-2296)
- Xue Zhong Liu (ORCID: https://orcid.org/0000-0002-4758-6470)
Institutions
- University of Miami (US)
- Dr. John T. Macdonald Foundation (US)
Publication Details
- Journal
- Genes
- Published
- 2025-04-29
- DOI
- https://doi.org/10.3390/genes16050526
- Citations
- 2
- Primary Topic
- Hearing, Cochlea, Tinnitus, Genetics
- Type
- article
- Field-Weighted Citation Impact
- 2.93