Inhibiting ADORA1 enhances glioma apoptosis and increases its sensitivity to anti-PD1 therapy
Our findings indicate that inhibiting ADORA1 can induce apoptosis in glioma cells and increase their sensitivity to anti-PD1 therapy. ADORA1 may serve as a prognostic marker for glioma and a potential target to enhance the effectiveness of anti-PD-1 therapy.
Authors
- Dongming Yan (ORCID: https://orcid.org/0000-0001-6036-2298)
- Zhi-yun Yu
- Wei Jiang (ORCID: https://orcid.org/0000-0003-2004-2665)
- Di Chen (ORCID: https://orcid.org/0000-0002-9854-8685)
- Huaping Gao
- Chao Yang (ORCID: https://orcid.org/0009-0001-2472-1393)
- Yiran Xu (ORCID: https://orcid.org/0009-0001-6290-1344)
- Xianzhi Liu (ORCID: https://orcid.org/0000-0002-6646-273X)
- Xueyuan Li (ORCID: https://orcid.org/0000-0002-0138-2296)
- Hongjiang Li
Institutions
- Precision for Medicine (United States) (US)
- Third Affiliated Hospital of Zhengzhou University (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-05-01
- DOI
- https://doi.org/10.3389/fonc.2025.1545780
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00