Contribution of Anti-type IV Collagen Antibodies From Kidney Basement Membrane to Increased Level of Urinary Immunoglobulin G in Nephritis Patients: A Comparison of Nephritic and Healthy Urine
Our results showed that NC1Abs and yp08Abs levels are raised in nephritis patients, accounting for the observed increase in IgG levels. Furthermore, antibodies against the α5 chain of collagen IV, which compose the basement membranes of the renal glomeruli and tubules, are responsible for the increased urine levels of IgG in nephritis patients.
Authors
- Yukisato Ishida
- Takeo Yokoyama
Institutions
- Collagen Medical (United States) (US)
- Tokyo Metropolitan University (JP)
Publication Details
- Journal
- Cureus
- Published
- 2025-05-01
- DOI
- https://doi.org/10.7759/cureus.83284
- Primary Topic
- Renal Diseases and Glomerulopathies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Tsukuba