Adverse Effect of Unani Pharmacopoeial Formulation Qurs-E-Mulayyin

Introduction: Herbal drug formulations, including Unani medicine, are widely used but can cause adverse effects if not properly administered. This case study reports an adverse drug reaction (ADR) to Qurs-e-Mulayyin, an Unani compound prescribed for chronic constipation. Methods: A 45-year-old female presented with chronic constipation and was prescribed multiple Unani medications, including Qurs-e-Mulayyin. After the third dose, she experienced severe vomiting, diarrhea, dizziness, and weakness. To assess the causality of this ADR, the patient was evaluated using the Naranjo ADR Probability Scale and De-challenge method. Results: The ADR was attributed to the presence of Croton tiglium and Saqmoonia in Qurs-e-Mulayyin, known for their strong purgative effects. After discontinuing the medication, the patient's symptoms resolved within 36 hours. Discussion: The case highlights the potential risks of Unani medications with hot and dry temperaments and emphasizes the need for careful patient monitoring. ADR reporting is crucial for preventing similar incidents. Conclusion: Qurs-e-Mulayyin should be administered with caution, and any adverse effects should be promptly reported for regulatory review.