Infection in Childhood Arterial Ischemic Stroke: Metagenomic Next-Generation Sequencing Results of the VIPS II Study
mNGS detected a variety of common childhood viruses in both patients with AIS and stroke-free children, suggesting that the type of infection does not explain AIS susceptibility. Rather, the alternative hypothesis regarding an unusual host immune response to common infections in the pathogenicity of AIS should be further explored.
Authors
- Nancy K. Hills (ORCID: https://orcid.org/0000-0002-1041-8182)
- Maham Zia
- Michael Morgan Dowling (ORCID: https://orcid.org/0000-0001-5058-6589)
- Melissa G. Chung (ORCID: https://orcid.org/0009-0005-8567-9175)
- Anne E. Wapniarski (ORCID: https://orcid.org/0000-0001-9937-2442)
- Michael R. Wilson (ORCID: https://orcid.org/0000-0002-8705-5084)
- Rebecca Ichord (ORCID: https://orcid.org/0000-0002-6863-0274)
- Joseph L. DeRisi (ORCID: https://orcid.org/0000-0002-4611-9205)
- Megan Barry (ORCID: https://orcid.org/0000-0002-5256-8269)
- Lauren A. Beslow (ORCID: https://orcid.org/0000-0003-0571-980X)
- Huichun Xu (ORCID: https://orcid.org/0000-0001-8118-9607)
- Max Wintermark (ORCID: https://orcid.org/0000-0002-6726-3951)
- Mark Thomas Mackay (ORCID: https://orcid.org/0000-0002-3787-1112)
- Heather J. Fullerton (ORCID: https://orcid.org/0000-0002-4828-1687)
- Jenny L. Wilson (ORCID: https://orcid.org/0000-0001-6677-869X)
- Prashanth Ramachandran (ORCID: https://orcid.org/0000-0001-8464-1355)
- Mary Wang
- Adam Kirton (ORCID: https://orcid.org/0000-0001-5209-3374)
- Charles Grose (ORCID: https://orcid.org/0000-0001-6884-6668)
- Shannon L. Carpenter (ORCID: https://orcid.org/0000-0002-0644-1689)
- Mary Rolfes (ORCID: https://orcid.org/0000-0003-3570-5353)
- Warren David Lo (ORCID: https://orcid.org/0000-0002-8079-8977)
- Lisa R. Sun (ORCID: https://orcid.org/0000-0003-4948-0415)
- Sarah Lee (ORCID: https://orcid.org/0000-0002-8821-6636)
- Tim Bernard
Institutions
- Northwestern University (US)
- University of Iowa (US)
- University of Maryland, Baltimore (US)
- Nationwide Children's Hospital (US)
- The Royal Melbourne Hospital (AU)
- The University of Texas MD Anderson Cancer Center (US)
- Oregon Health & Science University (US)
- University of California, San Francisco (US)
- Neurosciences Institute (US)
- Southwestern Medical Center (US)
- Peter Doherty Institute (AU)
- Chan Zuckerberg Initiative (United States) (US)
- The University of Texas Southwestern Medical Center (US)
- Stanford University (US)
Publication Details
- Journal
- Stroke
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1161/strokeaha.124.050548
- Citations
- 1
- Primary Topic
- Acute Ischemic Stroke Management
- Type
- article
- Field-Weighted Citation Impact
- 1.35