CD206 <sup>+</sup> IL-4Rα <sup>+</sup> Macrophages Are Drivers of Adverse Cardiac Remodeling in Ischemic Cardiomyopathy
Cardiac CD206<sup>+</sup>IL-4Rα<sup>+</sup> macrophages proliferate and expand in HF and are key mediators of pathological remodeling and fibrosis, in part through the secretion of FIZZ1. Inhibition of CD206<sup>+</sup> macrophage IL-4Rα signaling alleviates LV remodeling in ischemic cardiomyopathy.
Authors
- Guihua Zhou (ORCID: https://orcid.org/0000-0001-8867-8008)
- Sumanth D. Prabhu (ORCID: https://orcid.org/0000-0002-7247-7241)
- Steven M. Pogwizd (ORCID: https://orcid.org/0000-0002-7596-853X)
- Gregg Rokosh (ORCID: https://orcid.org/0000-0002-9214-2254)
- Qiongxin Wang
- Tariq Hamid (ORCID: https://orcid.org/0000-0002-4588-3754)
- Mohamed Ameen Ismahil (ORCID: https://orcid.org/0000-0002-7452-6123)
- Yujie Zhu (ORCID: https://orcid.org/0000-0002-4645-7669)
Institutions
- Washington University in St. Louis (US)
- University of Alabama at Birmingham (US)
- Wuhan University (CN)
- Zhongnan Hospital of Wuhan University (CN)
Publication Details
- Journal
- Circulation
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1161/circulationaha.124.072411
- Citations
- 9
- Primary Topic
- Cardiac Fibrosis and Remodeling
- Type
- article
- Field-Weighted Citation Impact
- 12.49