Inflammation via JAK-STAT/HIF-1α Drives Metabolic Changes in Pentose Phosphate Pathway and Glycolysis That Support Aortic Valve Cell Calcification
Inflammation reprograms VIC metabolism to support calcification by downregulating oxidative phase of pentose phosphate pathway and enhancing glycolytic flux and oxidative stress. These findings parallel the metabolic profile of stenotic VIC and provide novel therapeutic clues.
Authors
- Mariano Sánchez Crespo (ORCID: https://orcid.org/0000-0002-6149-154X)
- Jonathan T. Butcher (ORCID: https://orcid.org/0000-0002-9309-6296)
- Olimpio Montero (ORCID: https://orcid.org/0000-0002-0241-8756)
- Tania Sánchez‐Bayuela (ORCID: https://orcid.org/0000-0003-4773-7037)
- Carmen García‐Rodríguez (ORCID: https://orcid.org/0000-0002-7205-4572)
- Enrique Pérez-Riesgo (ORCID: https://orcid.org/0000-0002-3658-6803)
- J. Alberto San Román (ORCID: https://orcid.org/0000-0003-0764-0839)
- Iván Parra‐Izquierdo (ORCID: https://orcid.org/0000-0002-8831-1115)
- Javier López (ORCID: https://orcid.org/0000-0001-6193-629X)
- Cristina Gómez (ORCID: https://orcid.org/0009-0008-2121-6616)
- Mirian Peral-Rodrigo (ORCID: https://orcid.org/0009-0008-4649-7354)
Institutions
- Cornell University (US)
- Centro de Investigación en Red en Enfermedades Cardiovasculares (ES)
- Centro de Investigación Biomédica en Red (ES)
- Instituto de Biomedicina y Genética Molecular de Valladolid (ES)
- Hospital Clínico Universitario de Valladolid (ES)
Publication Details
- Journal
- Arteriosclerosis Thrombosis and Vascular Biology
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1161/atvbaha.124.322375
- Citations
- 8
- Primary Topic
- Cardiac Valve Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 11.11