Fibroblast dynamics during mammary oncogenesis: senescence, Wnt9a and beyond
Mammary gland fibroblasts are highly plastic and transition through distinct states during development and disease. A new study by Pascual et al (2025) provides a comprehensive single-cell atlas of murine mammary stromal cell hierarchies, revealing dysregulation of progenitor-driven fibroblast lineages in breast cancer and a senescence role of Wnt9a in cancer-associated myofibroblasts.
Authors
- Raghu Kalluri (ORCID: https://orcid.org/0000-0002-2190-547X)
- Viktoria Boeker (ORCID: https://orcid.org/0009-0004-9085-4479)
Institutions
- The University of Texas MD Anderson Cancer Center (US)
- Baylor College of Medicine (US)
- The University of Texas Medical Branch at Galveston (US)
- Rice University (US)
Publication Details
- Journal
- The EMBO Journal
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1038/s44318-025-00446-9
- Primary Topic
- Cancer Cells and Metastasis
- Type
- article
- Field-Weighted Citation Impact
- 0.00