CD8+ T Cell-Derived Perforin Exacerbates Dysbiosis and Inflammatory Bowel Disease via β-Hydroxybutyrate Suppression in Mouse Colonic Epithelium
CD8<sup>+</sup> T cell-derived perforin promoted colitis by disrupting gut microbiota composition through the suppression of β-hydroxybutyrate production. This study provides novel targets for therapeutic strategies of IBD.
Authors
- Stephen C. Pang (ORCID: https://orcid.org/0000-0001-7474-780X)
- Ye Zong (ORCID: https://orcid.org/0000-0003-4723-9265)
- Shiyang Huang (ORCID: https://orcid.org/0000-0002-1273-4621)
- Dong Zhang (ORCID: https://orcid.org/0000-0002-3404-5173)
- Mingyang Li (ORCID: https://orcid.org/0000-0003-1446-6381)
- Lijun Pan (ORCID: https://orcid.org/0000-0002-0541-5323)
- Dan Tian (ORCID: https://orcid.org/0000-0002-6894-2673)
- Yue Tian (ORCID: https://orcid.org/0000-0003-2522-7263)
- Wen Shi (ORCID: https://orcid.org/0000-0003-4957-7786)
Institutions
- Capital Medical University (CN)
- Beijing Chao-Yang Hospital, Capital Medical University (CN)
- National Clinical Research Center for Digestive Diseases (CN)
- Chinese Institute for Brain Research (CN)
- Beijing Friendship Hospital (CN)
- Beijing Chaoyang Emergency Medical Center (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2025-05-01
- DOI
- https://doi.org/10.2147/jir.s509875
- Citations
- 3
- Primary Topic
- Clinical Nutrition and Gastroenterology
- Type
- article
- Field-Weighted Citation Impact
- 3.36