Molecular Profiling of Nasopharyngeal Carcinoma Using the AACR Project GENIE Repository
This study presents a detailed genomic profile of NPC, identifying key mutations within established cancer-associated pathways. The identification of frequently mutated pathways (p53, NF-κB, and PI3K) suggests potential targets for novel therapies. Furthermore, distinct mutational landscapes in female and Asian NPC patients offer possibilities for precision therapeutic interventions.
Authors
- Vijay A. Patel (ORCID: https://orcid.org/0000-0002-8145-1721)
- Nicolas J. Jo (ORCID: https://orcid.org/0000-0001-7381-5620)
- John R. Crawford (ORCID: https://orcid.org/0000-0002-4100-7001)
- Michael G. Brandel (ORCID: https://orcid.org/0000-0001-7422-390X)
- Mariko Sato (ORCID: https://orcid.org/0000-0002-4748-4634)
- Michael L. Levy (ORCID: https://orcid.org/0000-0001-7545-8620)
- Sean P. Polster (ORCID: https://orcid.org/0000-0002-3229-5021)
- Beau Hsia (ORCID: https://orcid.org/0009-0009-6403-502X)
- Bastien A. Valencia‐Sanchez
- Jeeho D. Kim (ORCID: https://orcid.org/0000-0002-6691-3174)
- Roshan Dongre
- Gabriel Bitar
- Saif Alshaka
- Asritha Sure (ORCID: https://orcid.org/0009-0009-2582-9855)
- Julia Kuzniar
Institutions
- Rutgers, The State University of New Jersey (US)
- Boston University (US)
- Creighton University (US)
- Naval Medical Center San Diego (US)
- Children's Hospital of Orange County (US)
- Florida International University (US)
- University of California, Irvine (US)
- University of California San Diego (US)
- University of Chicago (US)
- Rady Children's Hospital-San Diego (US)
- Mayo Clinic in Florida (US)
- Rutgers New Jersey Medical School (US)
- Texas A&M University (US)
Publication Details
- Journal
- Cancers
- Published
- 2025-05-01
- DOI
- https://doi.org/10.3390/cancers17091544
- Citations
- 1
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.81