Harnessing the angiogenic potential of adipose-derived stromal vascular fraction cells with perfusion cell seeding
Eliminating the need for prolonged pre-culture offers a feasible and cost-effective strategy for advancing regenerative cell-based therapies by reducing pre-culture times while preserving therapeutic efficacy. Perfusion-based seeding offers significant short-term benefits, including enhanced vascularization and cell engraftment, though long-term differences compared to static seeding are minimal. Further investigation is needed to evaluate its potential in a diseased ischemic heart model.
Authors
- Oliver Reuthebuch (ORCID: https://orcid.org/0000-0003-1386-0686)
- Gregory Reid (ORCID: https://orcid.org/0000-0003-2089-3830)
- Giulia Cerino
- Jianlei Zhang (ORCID: https://orcid.org/0000-0002-9932-9265)
- Anna Marsano (ORCID: https://orcid.org/0000-0002-3084-0823)
- Giulia Milan (ORCID: https://orcid.org/0000-0001-6801-3914)
- Deborah Fusco
- Ludovic Melly (ORCID: https://orcid.org/0000-0002-0951-269X)
Institutions
- University Hospital of Basel (CH)
- University Hospital of Zurich (CH)
- Department of Biomedicine Basel (CH)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1186/s13287-025-04286-6
- Citations
- 2
- Primary Topic
- Angiogenesis and VEGF in Cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Universität Basel
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Servier