Labdane Diterpenoids from Leonotis ocymifolia with Selective Cytotoxic Activity Against HCC70 Breast Cancer Cell Line
The findings from this study warrant further investigation of <i>L. ocymifolia</i> for potential triple-negative breast cancer (TNBC) therapeutic agents, including potential chemical derivatization of <i>bis</i>-spiro labdane diterpenoid (<b>1</b>) to improve selectivity to TNBC over non-cancer cells.
Authors
- Vuyelwa J. Tembu (ORCID: https://orcid.org/0000-0002-7421-6467)
- Douglas Kemboi (ORCID: https://orcid.org/0000-0003-3771-128X)
- Comfort M. Nkambule (ORCID: https://orcid.org/0000-0002-5232-1514)
- Nyeleti Vukea (ORCID: https://orcid.org/0000-0002-5272-3345)
- Jo‐Anne de la Mare (ORCID: https://orcid.org/0000-0003-3808-6287)
- J Ncongwane
- Gerda Fouché (ORCID: https://orcid.org/0000-0002-2123-7774)
Institutions
- Tshwane University of Technology (ZA)
- Rhodes University (ZA)
- University of Kabianga (KE)
- University of Pretoria (ZA)
Publication Details
- Journal
- Diseases
- Published
- 2025-05-01
- DOI
- https://doi.org/10.3390/diseases13050140
- Primary Topic
- Natural product bioactivities and synthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Research Foundation
- Rhodes University
- Tshwane University of Technology