DSUP modified mesenchymal stem cells exert significant radiation protective effect by enhancing the hematopoietic niche
DSUP modified MSCs may serve as a new radioprotector for ARS. DSUP modified MSCs could attenuate radiation damage of HSPCs and promote HSPCs rapid recovery as well as hematopoietic reconstruction by providing a more functional niche after radiation, thereby reducing the occurrence of hematopoietic failure and improving survival rate.
Authors
- Junnian Zhou (ORCID: https://orcid.org/0000-0002-7782-234X)
- Yuhui Lin (ORCID: https://orcid.org/0000-0003-3280-4065)
- Wen Yue (ORCID: https://orcid.org/0000-0002-3935-360X)
- Jiafei Xi (ORCID: https://orcid.org/0000-0001-9751-2974)
- Tao Fan
- Yi Jia (ORCID: https://orcid.org/0000-0002-2896-6021)
- Biao Zhang (ORCID: https://orcid.org/0000-0001-6097-1878)
- Haiyang Wang (ORCID: https://orcid.org/0000-0001-7660-8133)
- Lixia Chen (ORCID: https://orcid.org/0000-0003-2196-1428)
- Quan Zeng (ORCID: https://orcid.org/0000-0001-8060-6130)
- Lili Wang (ORCID: https://orcid.org/0000-0002-8457-9616)
- Fudong Chen
- Mingfang Xiong
Institutions
- Nankai University (CN)
- Chinese PLA General Hospital (CN)
- Institute for Stem Cell Biology and Regenerative Medicine (IN)
- First Affiliated Hospital of Chinese PLA General Hospital (CN)
- Regenerative Medicine Institute (MX)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1186/s13287-025-04300-x
- Citations
- 2
- Primary Topic
- Effects of Radiation Exposure
- Type
- article
- Field-Weighted Citation Impact
- 2.72
Funders
- National Natural Science Foundation of China