Microtubule associated serine/threonine kinase-3 inhibits the malignant phenotype of breast cancer by promoting phosphorylation-mediated ubiquitination degradation of yes-associated protein
MAST3 was identified as a novel tumor suppressor protein in breast cancer, which directly regulates the expression of YAP through the non-dependent mammalian sterile-20-like (MST)-large tumor suppressor (LATS) classical signaling pathway, providing a theoretical and experimental basis for the development of small-molecule tumor inhibitors in breast cancer.
Authors
- Xuezhu Rong (ORCID: https://orcid.org/0000-0001-6623-5927)
- Wei Kang (ORCID: https://orcid.org/0000-0002-7617-6323)
- Jiang Du (ORCID: https://orcid.org/0000-0003-2147-569X)
- Ning Deng
- Qiang Han
Institutions
- Dalian University of Technology (CN)
- Dalian University (CN)
- Liaoning Cancer Hospital & Institute (CN)
Publication Details
- Journal
- Breast Cancer Research
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1186/s13058-025-02028-3
- Citations
- 1
- Primary Topic
- Hippo pathway signaling and YAP/TAZ
- Type
- article
- Field-Weighted Citation Impact
- 1.15
Funders
- National Natural Science Foundation of China
- Fundamental Research Funds for the Central Universities