Gelsolin Facilitates Estrogen Receptor Beta Nuclear Translocation and Transcriptional Repression of Genes Associated with Alzheimer Disease
Together, these data revealed the importance of the cytoskeletal protein, GSN, in regulating intracellular trafficking of nuclear receptors and demonstrate the first evidence of ERβ1 directly regulating two genes that are implicated in the progression of AD.
Authors
- Toni R. Pak (ORCID: https://orcid.org/0000-0002-9685-9754)
- Angela H. S. Fan
- Yoldas Yildiz (ORCID: https://orcid.org/0009-0002-8724-8334)
- Sarah C. Flury (ORCID: https://orcid.org/0000-0002-3497-1513)
- Amanda A. Hartoun
- Yan Ngai
Institutions
- Loyola University Chicago (US)
Publication Details
- Journal
- Receptors
- Published
- 2025-05-01
- DOI
- https://doi.org/10.3390/receptors4020010
- Primary Topic
- Estrogen and related hormone effects
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health