lute: estimating the cell composition of heterogeneous tissue with varying cell sizes using gene expression
Our software ( https://bioconductor.org/packages/lute ) can be used to enhance and improve existing deconvolution algorithms and can be used broadly for any type of tissue containing cell types with varying cell sizes.
Authors
- Louise A. Huuki-Myers (ORCID: https://orcid.org/0000-0001-5148-3602)
- Stephanie C. Hicks (ORCID: https://orcid.org/0000-0002-7858-0231)
- Kristen R. Maynard (ORCID: https://orcid.org/0000-0003-0031-8468)
- Sang Ho Kwon (ORCID: https://orcid.org/0000-0001-5328-0956)
- Sean K. Maden (ORCID: https://orcid.org/0000-0002-2212-4894)
- Leonardo Collado‐Torres (ORCID: https://orcid.org/0000-0003-2140-308X)
Institutions
- Johns Hopkins University (US)
- University of Cambridge (GB)
- Johns Hopkins Medicine (US)
- UK Dementia Research Institute (GB)
- Lieber Institute for Brain Development (US)
Publication Details
- Journal
- BMC Genomics
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1186/s12864-025-11508-x
- Citations
- 3
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Lieber Institute for Brain Development
- National Institutes of Health
- National Institute of Mental Health