Bone marrow mesenchymal stem cells alleviate liver fibrosis after rat liver transplantation through JAK1/STAT5 pathway
BMSCs alleviate hepatic cell damage, reduce hepatic cell-derived IL7, downregulate IL7R/JAK1/STAT5 in HSCs, thereby reducing HSCs' activation and ultimately alleviating liver fibrosis after liver transplantation.
Authors
- Chong Dong
- Zhuyuan Si (ORCID: https://orcid.org/0000-0002-7704-6432)
- Zhongyang Shen (ORCID: https://orcid.org/0000-0001-9481-0407)
- Tianran Chen (ORCID: https://orcid.org/0000-0001-6828-0852)
- Wei Gao (ORCID: https://orcid.org/0000-0003-2912-1116)
- Zhuolun Song (ORCID: https://orcid.org/0000-0001-5101-3950)
- Shengqiao Zhao (ORCID: https://orcid.org/0000-0003-1251-495X)
- Kai Wang (ORCID: https://orcid.org/0000-0001-8593-6366)
- Ruofan Wang (ORCID: https://orcid.org/0000-0002-9473-3912)
- Zhixin Zhang (ORCID: https://orcid.org/0000-0002-9219-5356)
- Chao Sun
Institutions
- Tianjin First Center Hospital (CN)
- Qilu Hospital of Shandong University (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1186/s13287-025-04353-y
- Citations
- 6
- Primary Topic
- Organ Transplantation Techniques and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 12.04
Funders
- National Natural Science Foundation of China