A Tissue Section-Based Mid-Infrared Spectroscopical Analysis of Salivary Gland Tumors Based on Enzymatic Deglycosylation
ATR-FTIR spectroscopy coupled with enzymatic deglycosylation can distinguish tumor and control tissues based on glycan-associated spectral differences. Application of the technique to benign/malignant SGT discrimination is hampered by spectral overlap and tumor heterogeneity. Further research will be necessary to explore other clustering algorithms and larger and more homogeneous datasets for improved diagnostic accuracy.
Authors
- Renaat Coopman (ORCID: https://orcid.org/0000-0002-0580-9074)
- Marijn M. Speeckaert (ORCID: https://orcid.org/0000-0001-9183-4390)
- Jasmien Wellens
- Hubert Vermeersch (ORCID: https://orcid.org/0000-0002-5037-4540)
- Robin Vanroose (ORCID: https://orcid.org/0000-0003-2857-7015)
- Sander De Bruyne (ORCID: https://orcid.org/0000-0002-9041-4404)
- Benjamin Denoiseux (ORCID: https://orcid.org/0000-0001-8375-4139)
- Joris Delanghe (ORCID: https://orcid.org/0000-0002-5702-6792)
- David Creytens (ORCID: https://orcid.org/0000-0002-6064-1673)
Institutions
- Ghent University Hospital (BE)
- Research Foundation - Flanders (BE)
- Ghent University (BE)
- Jessa Hospital (BE)
- Cancer Research Institute Ghent (BE)
Publication Details
- Journal
- Cancers
- Published
- 2025-05-01
- DOI
- https://doi.org/10.3390/cancers17091545
- Primary Topic
- Glycosylation and Glycoproteins Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00