Enhance the therapeutic efficacy of human umbilical cord-derived mesenchymal stem cells in prevention of acute graft-versus-host disease through CRISPLD2 modulation
Our study revealed that CRISPLD2 is a novel marker for identifying HUC-MSCs subpopulation with enhanced immunosuppressive functions. CRISPLD2 overexpression enhances the immunosuppressive function of HUC-MSCs by inhibiting P2Y11 receptor signalling. Targeting CRISPLD2 is a promising strategy to improve the therapeutic efficacy of HUC-MSCs in aGVHD while maintaining GVL activity.
Authors
- Lingyu Zeng (ORCID: https://orcid.org/0000-0002-6930-8965)
- Ke Sui (ORCID: https://orcid.org/0000-0002-5502-0389)
- Qingxiao Song (ORCID: https://orcid.org/0000-0001-9243-5666)
- Xiaoqi Wang (ORCID: https://orcid.org/0000-0001-8251-9102)
- Xiaodong Xie (ORCID: https://orcid.org/0000-0002-9088-8167)
- Qi Wang (ORCID: https://orcid.org/0000-0002-5287-6050)
- Xi Zhang (ORCID: https://orcid.org/0000-0002-8548-2832)
- Rui Wang (ORCID: https://orcid.org/0000-0002-5415-086X)
- Ya Zhou
- Yuxuan He (ORCID: https://orcid.org/0009-0002-3005-3421)
- Shijie Yang (ORCID: https://orcid.org/0000-0003-3452-3638)
- Jiang F. Zhong (ORCID: https://orcid.org/0009-0004-1501-5157)
- Ziyi Hu
- Qing Xu (ORCID: https://orcid.org/0000-0002-4785-2994)
- Z. Wang (ORCID: https://orcid.org/0009-0002-3116-2910)
- Yuxi Xu
Institutions
- Army Medical University (CN)
- Chongqing University (CN)
- Xuzhou Medical College (CN)
- Dalian Medical University (CN)
- Loma Linda University (US)
- Second Affiliated Hospital of Chongqing Medical University (CN)
- Xinqiao Hospital (CN)
- Chongqing University of Technology (CN)
- Chongqing Medical University (CN)
- China National Petroleum Corporation (China) (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1186/s13287-025-04321-6
- Citations
- 2
- Primary Topic
- Mesenchymal stem cell research
- Type
- article
- Field-Weighted Citation Impact
- 3.25
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Chongqing
- National Key Research and Development Program of China