Acute Alcohol‐Induced Changes Measured With Metabotropic Glutamate Receptor 5 Positron Emission Tomography
This proof-of-concept study demonstrates that [<sup>11</sup>C]ABP688 PET imaging is sensitive to the effects of acute alcohol consumption. The observed decrease in mGluR5 availability aligns with preclinical data potentially indicating acute increased extracellular glutamate concentrations following ethanol dosing. This imaging tool could be useful for future investigations into the acute effects of alcohol on the brain during abstinence and withdrawal.
Authors
- Gustavo A. Angarita (ORCID: https://orcid.org/0000-0001-5568-9878)
- Richard E. Carson (ORCID: https://orcid.org/0000-0002-9338-7966)
- Kelly Cosgrove (ORCID: https://orcid.org/0000-0003-1351-9576)
- Nakul Ravi Raval (ORCID: https://orcid.org/0000-0001-5637-7219)
- Yiyun Huang (ORCID: https://orcid.org/0000-0001-5269-3775)
- Stephanie S. O’Malley (ORCID: https://orcid.org/0000-0002-1976-2369)
- Ansel T. Hillmer (ORCID: https://orcid.org/0000-0002-8105-1381)
- Rachel Miller (ORCID: https://orcid.org/0000-0001-7387-1171)
- John Harrison Krystal (ORCID: https://orcid.org/0000-0001-6952-1726)
- Kelly Smart (ORCID: https://orcid.org/0000-0002-4775-6943)
Institutions
- Yale Cancer Center (US)
- Yale University (US)
- Connecticut Mental Health Center (US)
Publication Details
- Journal
- Addiction Biology
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1111/adb.70031
- Primary Topic
- Medical Imaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Yale University
- National Institute on Alcohol Abuse and Alcoholism
- NIH Clinical Center