Intrathecal Inflammatory Profile and Gray Matter Damage Predict Progression Independent of Relapse Activity in Early Multiple Sclerosis
A specific intrathecal inflammatory profile associated with TNF superfamily markers, CLn, and atrophy of several cortical and deep gray matter regions, assessed at time of diagnosis, is predictive of PIRA in early MS.
Authors
- Francesca B. Pizzini (ORCID: https://orcid.org/0000-0002-6285-0989)
- Francesco Crescenzo (ORCID: https://orcid.org/0000-0003-1396-7774)
- Albulena Bajrami (ORCID: https://orcid.org/0000-0002-6322-9545)
- Agnese Tamanti (ORCID: https://orcid.org/0000-0001-9972-4348)
- Richard Nicholas (ORCID: https://orcid.org/0000-0003-0414-1225)
- Owain W. Howell (ORCID: https://orcid.org/0000-0003-2157-9157)
- Federica Virla (ORCID: https://orcid.org/0009-0001-7346-9139)
- Stefano Ziccardi (ORCID: https://orcid.org/0000-0003-0426-7223)
- Stefania Montemezzi (ORCID: https://orcid.org/0000-0003-0216-2954)
- Ludwig Kappos (ORCID: https://orcid.org/0000-0003-4175-5509)
- Damiano Marastoni (ORCID: https://orcid.org/0000-0003-0358-9431)
- Valentina Camera (ORCID: https://orcid.org/0000-0002-4925-9000)
- Roberta Magliozzi (ORCID: https://orcid.org/0000-0001-8284-7763)
- Matteo Foschi (ORCID: https://orcid.org/0000-0002-0321-7155)
- Massimiliano Calabrese (ORCID: https://orcid.org/0000-0002-3362-7403)
- Antonio Scalfari (ORCID: https://orcid.org/0000-0002-7757-0293)
- Bruno Bonetti (ORCID: https://orcid.org/0000-0002-3944-4165)
- Daniela Anni (ORCID: https://orcid.org/0000-0002-5825-6303)
- Gian Marco Schiavi (ORCID: https://orcid.org/0000-0002-4851-6458)
- Ermanna Turano (ORCID: https://orcid.org/0000-0002-0760-1787)
- Elisa Colato (ORCID: https://orcid.org/0000-0002-4101-7058)
- Cristina Granziera (ORCID: https://orcid.org/0000-0002-4917-8761)
- Maddalena Guandalini (ORCID: https://orcid.org/0000-0003-2341-9253)
- Chiara Eccher
Institutions
- University of Verona (IT)
- Queen Mary University of London (GB)
- University of L'Aquila (IT)
- Charing Cross Hospital (GB)
- University Hospital of Basel (CH)
- Swansea University (GB)
- Ospedale "Santa Maria delle Croci" di Ravenna (IT)
- Azienda Ospedaliera Universitaria Integrata Verona (IT)
- National Hospital for Neurology and Neurosurgery (GB)
- Amsterdam University Medical Centers (NL)
- University College London (GB)
- Imperial College London (GB)
Publication Details
- Journal
- Neurology Neuroimmunology & Neuroinflammation
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1212/nxi.0000000000200399
- Citations
- 4
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 5.89