Predicting Transvaginal Surgical Mesh Exposure Outcomes Using an Integrated Dataset of Blood Cytokine Levels and Medical Record Data: Machine Learning Approach
Supervised machine learning models demonstrated improved prediction accuracy when trained using a composite dataset that combined patient medical record data and biomaterial-induced blood cytokine levels, surpassing the performance of models trained with either dataset in isolation. This result underscores the advantage of integrating health care data with blood biomarkers, presenting a promising avenue for predicting surgical outcomes in not only POP mesh procedures but also other surgeries involving biomaterials. Such an approach has the potential to enhance informed decision-making for both patients and surgeons, ultimately elevating the standard of patient care.
Authors
- Lauren M. Wolf (ORCID: https://orcid.org/0000-0002-0389-6450)
- Nicholas Boltin (ORCID: https://orcid.org/0000-0003-2808-8211)
- Mihyun Lim Waugh (ORCID: https://orcid.org/0000-0002-9171-9138)
- Richard L. Goodwin (ORCID: https://orcid.org/0000-0002-2537-2535)
- Thomas L. Wheeler (ORCID: https://orcid.org/0000-0001-9658-9101)
- Ronnie D. Horner (ORCID: https://orcid.org/0000-0002-9967-216X)
- Melissa A. Moss (ORCID: https://orcid.org/0000-0003-4092-5297)
- Patti C. Parker (ORCID: https://orcid.org/0000-0003-0907-1705)
- Tyler Mills
Institutions
- Prisma Health (US)
- University of South Carolina (US)
- Spartanburg Regional Healthcare System (US)
- University of Nebraska Medical Center (US)
Publication Details
- Journal
- JMIR Formative Research
- Published
- 2025-05-01
- DOI
- https://doi.org/10.2196/59631
- Primary Topic
- Endometriosis Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00