Proteomic signatures and predictive modeling of cadmium-associated anxiety in middle-aged and elderly populations: an environmental exposure association study
This first integrative environmental-proteomic study highlights cadmium's synergistic role in anxiety pathophysiology and psychiatric comorbidity. The predictive model offers translatable potential for early risk stratification, while CCDC126 provides mechanistic insights for targeted interventions in populations exposed to environmental pollutants.
Authors
- Shaoxin Huang (ORCID: https://orcid.org/0000-0001-9801-4133)
- Mi Tian (ORCID: https://orcid.org/0000-0002-6446-1995)
- Qiwen Chen (ORCID: https://orcid.org/0000-0003-3141-1817)
- Zelong Xing
- Yinghui Yin
- Jie Li (ORCID: https://orcid.org/0000-0001-9359-3586)
- Hao Gao (ORCID: https://orcid.org/0009-0003-4218-3095)
- Qihan Zhao (ORCID: https://orcid.org/0009-0000-6708-266X)
- Sheng Wan (ORCID: https://orcid.org/0000-0003-0228-3449)
- Yong Yang (ORCID: https://orcid.org/0000-0001-6729-6086)
- Zhenzhong Liu (ORCID: https://orcid.org/0000-0002-8386-0836)
- Xinxin Shi (ORCID: https://orcid.org/0009-0006-2003-6635)
- Zi-Qin Ji
Institutions
- North Sichuan Medical University (CN)
- Jiujiang University (CN)
- Jiujiang First People's Hospital (CN)
- Nanchang Center for Disease Control and Prevention (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1186/s12967-025-06466-7
- Citations
- 2
- Primary Topic
- Heavy Metal Exposure and Toxicity
- Type
- article
- Field-Weighted Citation Impact
- 2.40
Funders
- National Natural Science Foundation of China
- Postdoctoral Research Foundation of China