Resulting Sequelae of an Immunosuppressive State in a Pediatric Patient Status Post Bone Marrow Transplant for the Curative Management of Myelodysplastic Syndrome

Myelodysplastic syndrome is a clonal disorder of hematopoietic stem cells leading to dysplasia and ineffective hematopoiesis. The typical presentation is asymptomatic with incidental lab findings consistent with varying degrees of pancytopenia. This syndrome is commonly diagnosed in older individuals and tends to result from chemical and/or radiation exposures; however, this patient presents as a unique manifestation of myelodysplastic syndrome in a six-month-old male. For curative management, the patient had an initial haploidentical hematopoietic stem cell transplant, followed by another, due to early graft rejection. In the following years leading to the present time, the patient has had complications due to a persistent immunodeficient state. He has been evaluated and managed for seizures, anemia, chemotherapy-induced cardiomyopathy, hypogammaglobinemia, failure to thrive, recurrent infections, graft versus host disease, malnutrition, and hypertransaminasemia with hepatosplenomegaly. He has had resolution of his cardiomyopathy and seizures but continues to manage his persistent immunodeficiencies, hepatomegaly, and slow weight gain. It is hard to discern if the multitude of dysfunctions arises from pharmacologically induced immunodeficiency, from parental and environmental neglect, if the manifestations compounded one another, or if the above factors combined to create the unique constellation of clinical manifestations. This patient provides insight into the complexities associated with understanding unique manifestations in dysplastic and oncological conditions, as well as managing complications arising from treatment. This case raises awareness of medical complications in the context of parental neglect and the importance of managing them both. The authors received consent from the patient's guardian to use their data for this report.