CircPAPPA binds to PAPPA and promotes trophoblast proliferation in spontaneous abortion through the formation of circPAPPA-PAPPA complexes
Altogether, our study shows that circPAPPA binds to PAPPA, enhancing trophoblast proliferation in vitro, and suggests that targeting the circPAPPA-PAPPA interaction might be a novel therapeutic strategy for addressing spontaneous abortion.
Authors
- Shengtao Zhou (ORCID: https://orcid.org/0000-0001-8322-5536)
- Shan Lü (ORCID: https://orcid.org/0000-0001-6448-2238)
- Hong-Wei Zhou (ORCID: https://orcid.org/0000-0003-1771-6905)
- Aihua Wu (ORCID: https://orcid.org/0000-0002-0474-802X)
- Xiaojing Hou (ORCID: https://orcid.org/0000-0003-1044-3617)
- Siqi Chen (ORCID: https://orcid.org/0000-0002-9498-3823)
- Liang Yu (ORCID: https://orcid.org/0009-0007-3922-3454)
- Bo Liu (ORCID: https://orcid.org/0009-0005-6182-8172)
Institutions
- Guangzhou University of Chinese Medicine (CN)
Publication Details
- Journal
- Gene
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1016/j.gene.2025.149538
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00