Knockdown of Plexin C1 induces epithelial-to-mesenchymal transition and confers resistance to multikinase inhibitors in hepatocellular carcinoma cells
PLXNC1 expression may serve as a predictive biomarker for MKI efficacy in HCC and provides a potential avenue for personalized therapeutic strategies. Further clinical validation is required to incorporate PLXNC1 into routine diagnostic and treatment protocols for HCC.
Authors
- Maide Şeker (ORCID: https://orcid.org/0000-0003-0013-2516)
- Dilek Yavuzer (ORCID: https://orcid.org/0000-0002-6024-7967)
- Sude Topkaraoğlu (ORCID: https://orcid.org/0000-0002-7680-7156)
- Arzu Aysan (ORCID: https://orcid.org/0000-0001-7217-3347)
- Tamer Yağcı (ORCID: https://orcid.org/0000-0003-2050-7477)
- Şevval Dik (ORCID: https://orcid.org/0000-0002-6440-0201)
- Gamze Güngör Topcu (ORCID: https://orcid.org/0000-0002-0006-8844)
- Melike Binnur Bahçekapili (ORCID: https://orcid.org/0009-0001-7950-2155)
Institutions
- Gebze Technical University (TR)
- Sağlık Bilimleri Üniversitesi (TR)
- University of Health Sciences Antigua (AG)
Publication Details
- Journal
- TURKISH JOURNAL OF BIOLOGY
- Published
- 2025-04-25
- DOI
- https://doi.org/10.55730/1300-0152.2739
- Primary Topic
- Axon Guidance and Neuronal Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Türkiye Bilimsel ve Teknolojik Araştırma Kurumu