Cancer Therapy-related Cardiotoxicity is Associated with Distinct Alterations of the Myocardial Lipidome
Anthracycline-induced cardiotoxicity leads to distinct alterations of the myocardial lipidome. Increased levels of myocardial lysolipids were identified as a novel lipidomic trait in AIC, which appears to be distinct from other causes of heart failure. Further research studying pharmacological interventions in lysolipid metabolism for prevention and therapy of AIC is warranted.
Authors
- István Baczkó (ORCID: https://orcid.org/0000-0002-9588-0797)
- Hendrik Milting (ORCID: https://orcid.org/0000-0001-9722-0007)
- Vera Braun
- Niklas Beyhoff (ORCID: https://orcid.org/0000-0001-9140-2336)
- Anna Foryst‐Ludwig
- Ulf Landmesser (ORCID: https://orcid.org/0000-0002-0214-3203)
- Ulrich Kintscher (ORCID: https://orcid.org/0000-0001-7386-0990)
Institutions
- University of Szeged (HU)
- Heart and Diabetes Center North Rhine-Westphalia (DE)
- Deutsches Herzzentrum der Charité (DE)
- German Centre for Cardiovascular Research (DE)
- Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- European Journal of Heart Failure
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1002/ejhf.3656
- Citations
- 3
- Primary Topic
- Chemotherapy-induced cardiotoxicity and mitigation
- Type
- article
- Field-Weighted Citation Impact
- 4.16
Funders
- Deutsches Zentrum für Herz-Kreislaufforschung
- European Society of Cardiology
- Deutsche Forschungsgemeinschaft
- Szegedi Tudományegyetem
- Berlin Institute of Health
- National Research, Development and Innovation Office