Human cytochrome P450 enzymes catalyze oxidative metabolism of pectolinarigenin to generate a more active Nrf2 agonist
CYPs catalyze PEC-4'-<i>O</i>-demethylation to generate a more active Nrf2 agonist (HIS), which shows more efficacious hepatoprotective effects against APAP-induced hepatocyte injury.
Authors
- Huixin Liu (ORCID: https://orcid.org/0000-0002-8981-9981)
- Dong‐Zhu Tu
- Jia-Hao Gong
- Qian Li (ORCID: https://orcid.org/0000-0002-2393-1938)
- Feng Zhang (ORCID: https://orcid.org/0000-0003-4556-8276)
- Yanyan Deng
- Peiqi Liu (ORCID: https://orcid.org/0000-0002-6165-3721)
- Jing Hu (ORCID: https://orcid.org/0000-0003-3288-7067)
- Guangbo Ge (ORCID: https://orcid.org/0000-0002-8437-9155)
Institutions
- Zunyi Medical University (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Chinese Herbal Medicines
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1016/j.chmed.2025.04.008
- Citations
- 2
- Primary Topic
- Genomics, phytochemicals, and oxidative stress
- Type
- article
- Field-Weighted Citation Impact
- 1.61